Comparative Proteomics Analysis of Human Liver Microsomes and S9 Fractions
نویسندگان
چکیده
منابع مشابه
Dataset from proteomic analysis of rat, mouse, and human liver microsomes and S9 fractions
Rat, mouse and human liver microsomes and S9 fractions were analyzed using an optimized method combining ion exchange fractionation of digested peptides, and ultra-high performance liquid chromatography (UHPLC) coupled to high resolution tandem mass spectrometry (HR-MS/MS). The mass spectrometry proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteo...
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Dehydroepiandrosterone (DHEA) and 3beta-hydroxy-5alpha-androstan-17-one (epiandrosterone, EpiA) are both precursors for 7alpha- and 7beta-hydroxylated metabolites in the human brain. These 7-hydroxylated derivatives were shown to exert anti-glucocorticoid and neuroprotective effects. When these steroids are administered per os to humans, the first organ encountered is the liver, where extensive...
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ژورنال
عنوان ژورنال: Drug Metabolism and Disposition
سال: 2019
ISSN: 0090-9556,1521-009X
DOI: 10.1124/dmd.119.089235